Benign familial chorea: an association with intellectual impairment.
نویسندگان
چکیده
Twenty-four members of a family with benign familial chorea underwent testing for evidence of intellectual impairment. Lower verbal intelligence was found in affected individuals compared to unaffected family members, as were deficits in verbal abstract concept formation. These results challenge the notion that benign familial chorea uniformly spares the intellect in all kindreds.
منابع مشابه
Benign (non-paroxysmal) familial chorea. Paediatric perspectives.
We describe a non-progressive choreo-athetoid disorder of early onset, present in three families. There were no appreciable abnormalities in pregnancy, during the perinatal period, or in infancy. In each case the family history suggested transmission as an autosomal dominant trait, the gene showing diminished penetrance. Other families have been reported with the disorder and such titles as ben...
متن کاملADCY5 Mutations and Benign Hereditary Chorea
Investigators from the Institute of Neurology, London, UK, and centers in Italy, Germany, and Greece, studied 18 unrelated cases of benign hereditary chorea BHC (7 familial, 11 sporadic) who were negative for NKX2-1 mutations.
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 47 5 شماره
صفحات -
تاریخ انتشار 1984